Product Description
| Catalog Number | E-AB-22121 |
| Product Name | SMAD3 Monoclonal Antibody |
| Background | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.. |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4. |
| Applications | WB,IHC-p |
| Reactivity | Human,Mouse,Rat |
| Host | Mouse |
| Clone | Clone:6F3 |
| Swissprot | P84022 |
| Dilution | WB 1:1000-2000, IHC 1:100-200 |
| Storage | Store at -20°C. Avoid freeze / thaw cycles.. |
| Document |
Manufacturer by Elabscience
This product is for Research Purposes Only