Product Description
| Catalog Number | E-AB-22127 |
| Product Name | ACTN1 Monoclonal Antibody |
| Background | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.. |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4. |
| Applications | IHC-p |
| Reactivity | Human,Mouse,Rat |
| Host | Mouse |
| Clone | Clone:1D4 |
| Swissprot | P12814 |
| Dilution | IHC 1:100-200 |
| Storage | Store at -20°C. Avoid freeze / thaw cycles.. |
| Document |
Manufacturer by Elabscience
This product is for Research Purposes Only