Anti-Human XBP1

Product Description

* Background

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein and was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has also been found that the same agents that cause an ER stress response, the unfolded protein response (UPR), also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter. In the UPR pathway, two isoforms of the protein are made. The function of the shorter isoform (XBP-1U) has not been determined, while the longer isoform (XBP-1S) is the active isoform. The longer isoform is generated by a process in which two adjecent stem loop structures in the mRNA are recognized by IRE1, resulting in the loss of 26 nt from the mRNA and a frameshift in the CDS. Finally, a pseudogene has been identified and localized to chromosome 5. [NCBI Entrez Gene Summary]

*Quality of Control

Data Sheet BMR00292 (PDF File)

Western blot protocol (PDF File)

Caution must be taken to avoid contact with skin or eyes. In such a case, rinse thoroughly at once with water. Do not ingest, inhale, or swallow. Seek medical attention immediately. Wear appropriate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful. The vial is prone to fall over. Use caution, especially when the lid is off .

FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.

Manufactured by : Bio Matrix Research, Inc.