Product Description
| Product Name | Cat# | Clone# | Unit Size | Isotype | Applications | Reactivity |
| Anti-Human PRKAR1A | BMR00524 | 3546C2a | 100ug/ml (1ml) | IgG1 | DB,WB | Hu |
* Background
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Functional null mutations in this gene cause Carney complex (CNC), an autosomal dominant multiple neoplasia syndrome. This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. Three alternatively spliced transcript variants encoding the same protein have been observed. [NCBI Entrez Gene Summary]
*Quality of Control
Data Sheet BMR00524 (PDF File)
Western blot protocol (PDF File)
| Antibody Concentration | 100 ug/ml (1.0 ml) |
| Host Species | Mouse |
| Preparation | This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. |
| Sterility | Filtered through a 0.22 um membrane. |
| Alternate Names | CAR, CNC, CNC1, PKR1, TSE1, PPNAD1, PRKAR1, MGC17251, DKFZp779L0468 |
| Accession No. | NM_002734 |
Caution must be taken to avoid contact with skin or eyes. In such a case, rinse thoroughly at once with water. Do not ingest, inhale, or swallow. Seek medical attention immediately. Wear appropriate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful. The vial is prone to fall over. Use caution, especially when the lid is off .
FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Manufactured by : Bio Matrix Research, Inc.
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