Product Description
| Product Name | Cat# | Clone# | Unit Size | Isotype | Applications | Reactivity |
| Anti-Human CBFA2T2 | BMR00150 | CBF5I134 | 100ug/ml (1ml) | IgG1 | DB,WB,FC,ICC | Hu |
* Background
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [NCBI Entrez Gene Summary]
*Quality of Control
Data Sheet BMR00150 (PDF File)
Western blot protocol (PDF File)
Flow cytometry protocol (PDF File)
Immunocytochemistry protocol (PDF File)
| Antibody Concentration | 100 ug/ml (1.0 ml) |
| Host Species | Mouse |
| Preparation | This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. |
| Sterility | Filtered through a 0.22 um membrane. |
| Alternate Names | MTGR1, EHT, ZMYND3 |
| Accession No. | BC040344 |
Caution must be taken to avoid contact with skin or eyes. In such a case, rinse thoroughly at once with water. Do not ingest, inhale, or swallow. Seek medical attention immediately. Wear appropriate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful. The vial is prone to fall over. Use caution, especially when the lid is off .
FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Manufactured by : Bio Matrix Research, Inc.
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